Accumulation of Exogenous ^<45>Ca after Middle Cerebral Artery Occlusion in Rats

概要

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The distribution of exogenous ^<45>Ca in the focal ischemia rat model (middle cerebral artery occlusion) was studied using ^<45>Ca autoradiography. High ^<45>Ca accumulations were observed in the frontal cortex and caudate-putamen corresponding with morphological damage shown by HE staining. Regional ^<45>Ca concentrations were calculated from the optical density on the ^<45>Ca autoradiograms. Rapid uptake of ^<45>Ca in the ischemic brain occurred during the first 5 hours, and continued more slowly between 5 and 24 hours after ischemia. The area of ^<45>Ca accumulation was also expanded between 5 and 24 hours. An area of low ^<45>Ca concentration around the area of high accumulation developed 5 hours after ischemia, which presumably accumulated ^<45>Ca between 5 and 24 hours after ischemia. The lower concentration of ^<45>Ca in the periphery of ischemia may result from: 1) a decrease in the total amount of calcium due to narrowing of extracellular space accompanied by cytotoxic edema, and 2) delayed accumulation of exogenous ^<45>Ca due to reduced clearance of extracellular fluid.
日本脳神経外科学会の論文
1994-02-15