Diffuse Low-density Areas in White Matter on CT Scans After Intracarotid ACNU Infusion : Report of Three Cases
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概要
- 論文の詳細を見る
Since 1984, we have treated 11 malignant glioma patients with intracarotid infusion of ACNU [1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride] in addition to surgical removal and irradiation. We experienced three patients, who showed clinical manifestation of leukoencephalopathy and computed tomographic (CT) findings of diffuse low-density areas in the white matter on the side of ACNU infusion. Two of the three patients showed an additional CT finding of ring enhancement in the temporo-occipital region. The histological diagnosis of the first case was radiation necrosis, while that of the others was recurrent tumor with coagulation necrosis in the surrounding brain. Our experience suggests that intracarotid ACNU infusion increases the hazard of radiation necrosis, and the optimum dose and effective mode of administration should be evaluated.
- 日本脳神経外科学会の論文
- 1990-09-15
著者
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佐古 和廣
Department of Neurosurgery, Asahikawa Medical College
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OKAZAKI Shinya
Department of Cardiovascular Medicine, Juntendo University
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YONEMASU Yukichi
Department of Neurosurgery, Neurological Institute, Kyushu University
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Okazaki Shinya
Department Of Applied Chemistry & Biochemistry Faculty Of Engineering Kumamoto University
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Okazaki Shinya
Departments Of Neurosurgery Asahikawa Medical College
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FUJITA Tsutomu
Department of Materials Technology, Faculty of Engineering, Chiba University
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TAKEI Hidetoshi
Department of Radiology, Asahikawa Medical College
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DAITA Go
Department of Neurosurgery, Asahikawa Medical College
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HODOZUKA AKIRA
Department of Neurosurgery, Asahikawa Medical College
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Yonemasu Yukichi
Department Of Neurosurgery Asahikawa Medical College
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Yonemasu Yukichi
Departments Of Neurosurgery Asahikawa Medical College
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Fujita Tsutomu
Departments Of Neurosurgery Asahikawa Medical College
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Daita Go
Departments Of Neurosurgery Asahikawa Medical College
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Daita Go
Department Of Neurosurgery Asahikawa Medical College
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Hodozuka Akira
Department Of Neurosurgery Asahikawa Medical College
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Hodozuka Akira
Departments Of Neurosurgery Asahikawa Medical College
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SAKO Kazuhiro
Department of Neurosurgery, Asahikawa Medical College
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Takei Hidetoshi
Departments Of Radiology Asahikawa Medical College
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Takei Hidetoshi
Department Of Radiology Asahikawa Medical College
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Sako Kazuhiro
Department Of Neurosurgery Asahikawa Medical College
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Sako Kazuhiro
Departments Of Neurosurgery Asahikawa Medical College
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