Relationship Between ^<22>Na Distribution and Cerebral Blood Flow in Ischemic Gerbil Brain

概要

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Sodium transport in the early postischemic period was studied using Mongolian gerbils with right common carotid artery ligation. [^<22>Na]sodium chloride ([^<22>Na]NaCl) was infused immediately after, 10 minutes before, and 4 hours before carotid ligation, and the ^<22>Na distribution was measured in symptomatic animals by autoradiography 1 hour after ischemia. Regional cerebral blood flow was determined by [^<14>C]iodoantipyrine autoradiography. The specific gravity of the brain was measured in symptomatic gerbils 1 and 2 hours after carotid ligation by a gradient column. There was a low uptake of ^<22>Na in the ischemic core and a high uptake in the ischemic periphery when the tracer was given 10 minutes before or immediately after ischemia. In contrast, tracer given 4 hours before ischemia showed an increased radioactivity in both the ischemic core and periphery. It is suggested that increased sodium in the ischemic core is due to a decreased sodium clearance rate and increased sodium in the ischemic periphery is due to some active transport process.
日本脳神経外科学会の論文
1991-05-15