Measurement of Cerebral Blood Flow, Cerebral Blood Volume, and Cerebral Capillary Permeability in Glioma-bearing Rats
スポンサーリンク
概要
- 論文の詳細を見る
Effective chemotherapy and radiation therapy of brain tumors require knowledge of the cerebral circulatory dynamics involved. In this study, regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), and regional cerebral capillary permeability (rCP) were measured in Wistar King Aptekman rats bearing experimental KEG-1 gliomas. These parameters were assessed by auto-radiography with ^<14>C-iodoantipyrine, ^<14>C-deoxyglucose-labeled red blood cells, and ^<14>C-aminoisobutyric acid, respectively. rCBF within the tumor was approximately one third that in the contralateral cortex and was consistently higher in the periphery than in the center of the tumor. In the periphery of the tumor, rCBV was approximately twice that in the contralateral cortex, but it was very low in the center of the tumor. Throughout the tumor, rCP was sharply increased relative to that measured in the contralateral cortex, and the increase was especially pronounced in the central portion. Thus, rCBF, rCBV, and rCP each appeared to vary within the tumor, implying that the combined use of lipid- and water-soluble chemotherapeutic agents is reasonable. Measurement of these parameters may also provide indices of radiation sensitivity.
- 日本脳神経外科学会の論文
- 1990-02-15
著者
-
YONEMASU Yukichi
Department of Neurosurgery, Neurological Institute, Kyushu University
-
Yonemasu Yukichi
Department Of Neurosurgery Asahikawa Medical College
-
AIZAWA Shizuka
Department of Neurosurgery, Asahikawa Medical College
-
SAKO Kazuhiro
Department of Neurosurgery, Asahikawa Medical College
-
Aizawa Shizuka
Department Of Neurosurgery Asahikawa Medical College
-
Sako Kazuhiro
Department Of Neurosurgery Asahikawa Medical College
-
YONEMASU Yukichi
Department of Neurosurgery, Asahikawa Medical College
-
Sako Kazuhiro
Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University
関連論文
- Malignant Primary Meningeal Tumors
- Surgical Treatment of Functioning Pituitary Adenoma
- B-35. Air Embolism during Neurosurgical Operation in the Sitting Position
- Magnetic Resonance Imaging in Kainic Acid-induced Limbic Seizure Status in Cats
- Glial Cyst in the Thalamus with Intracystic Hemorrhage : Case Report
- Hypervascularity in Lhermitte-Duclos Disease : Case Report
- The Role of the Paraventricular Nucleus and Pituitary Gland in Morphine Analgesia
- Measurement of Cerebral Blood Flow, Cerebral Blood Volume, and Cerebral Capillary Permeability in Glioma-bearing Rats
- Cavernous Sinus Invasion by Pituitary Adenomas : Relationship between Magnetic Resonance Imaging Findings and Histologically Verified Dural Invasion
- Diffuse Low-density Areas in White Matter on CT Scans After Intracarotid ACNU Infusion : Report of Three Cases
- Aneurysms Located at the Horizontal Segment of the Anterior Cerebral Artery or the Middle Cerebral Artery
- Intracrania1 Malignant Teratoma Diagnosed in a Fetus : Case Report
- Relationship Between ^<22>Na Distribution and Cerebral Blood Flow in Ischemic Gerbil Brain
- Accumulation of Exogenous ^<45>Ca after Middle Cerebral Artery Occlusion in Rats
- Ruptured Aneurysm With Delayed Distal Coil Migration Requiring Surgical Treatment : Case Report
- Evaluation of Models for Predicting Spray Mist Diameter for Scaling-Up of the Fluidized Bed Granulation Process
- The Effects of Oxiracetam (CT-848) on Local Cerebral Glucose Utilization after Focal Cerebral Ischemia in Rats.