a.抗リン脂質抗体症候群(2.生殖)

概要

論文の詳細を見る
Antibodies to phospholipid antigens (aPL) are associated with thrombosis and recurrent pregnancy losses. Clinical features (venous or arterial thrombosis, recurrent pregnancy loss) in conjunction with positive laboratory findings (positive IgG or IgM anticardiolipin antibodies, or positive lupus anticoagulant tests) will satisfy criteria for diagnosis of the aPL syndrome. Contemporary data show many aPL target phospholipid-binding plasma proteins and not phospholipids. Some aPL recognize phospholipids directly, however, the majority and many which correlate with pathology target phospholipid binding proteins. Published data indicate that aPL represent a constellation of antibodies with multiple specificities. Insight into mechanisms responsible for aPL-associated thrombosis and pregnancy loss should provide a basis for treatment. The obstetric management of women with aPL syndrome remains controversial. Despite recent advances, the controversies have been fuelled by our limited understanding of the multifactorial causes of aPL-associated pregnancy loss and the lack of data from randomized studies. Recently, combined treatment with aspirin and heparin has been demostrated in two randomized studies to lead to a high live birth rate in aPL pregnancies. Large multi-center, randomized controlled studies are necessary to address the lack of existing date.
社団法人日本産科婦人科学会の論文
2002-08-01