HBs 抗原陽性成人型小児肝癌の1例

概要

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A 14-year-old girl having hepatocellular carcinoma (liver cell carcinoma) associated with positive hepatitis B surface antigen (HB_s-Ag) was reported. She had been suffering from type B hepatitis when she was 9 years old. The tumor of 13cm in diameter was located in the left hepatic lobe. Left hepatic lobectomy was performed. HB_s-Ag was demonstrated in serological examination. Histologically Orcein-stain-positive cells were present in non-neoplastic liver tissues. She was suspected to be a case of maternal transmission because her mother and brother were HB_s-Ag positive carries. There was no cirrhosis in the liver tissue. Nine months after the hepatectomy, lung mstastasis was found out. The chemotherapy was not effective, and 14 months after the first surgery, the right lower lobectomy was done. However she died 8 days after the second operation. Review of the Japanese literatures disclosed 10 other cases of HB_s-Ag positive hepatocellular carcinoma in childhood. They may imply the significant relationship between HB virus and hepatocellular carcinoma not only in adult but also in childhood.
日本小児外科学会の論文
1988-02-20