EFFECT OF THE PROTEIN-BINDING POLYSACCHARIDE, PS-K, ON RADIOTHERAPY OF UTERlNE CERVICAL CARCINOMA
スポンサーリンク
概要
- 論文の詳細を見る
子宮頚癌の放射線照射効果すなわち放射線感受性が,PS-Kの投与によって如何なる影響を受けるかを病理組織学的に研究した.PS-K投与例は非投与例と比較して,放射線感受性良好例が著明に増加し,不良例の減少を認めた(PS-K非投与例では良好24.9%,中等度30.3%,不良44.8%であるのに対し,PS-K投与例では良好54.8%,中等度26.2%,不良19.0%).そしてこれら両老間には1%以下の危険率で有意差を認めた.すなわち放射線との併用においてPS-Kはantitumor effectが存在することが判明した.この場合のPS-Kの作用機序は放射線に対する増感効果によることが強く示唆された.一方,病理組織学的にみて子宮頚部の病巣内や領域リンパ節内に免疫反応の関与を示す所見がみられたが,この免疫反応がどの程度癌細胞の障害に関与しているかについては,今回の研究では十分には明かにし得なかった.
- 社団法人日本産科婦人科学会の論文
- 1979-07-01
著者
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NOGUCHI Hiroshi
Departments of Pharmacokinetics and Pharmacodynamics, Pharmacognosy and Global Center of Excellence
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Fukuta Toru
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine
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Fukuta Toru
Department Of Obstetrics & Gynecology Shinshu University School Of Medicine
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IWAI Shoji
Department of Obstetrics and Gynecology, Shinshu University School of Medicine
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Tsukahara Yoshiharu
Department Of Obstetrics And Gynecology Yamanashi Medical College
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Tsukahara Yoshiharu
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine Matsumoto
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Tsukahara Yoshiharu
Department Of Obstetrics And Gynecology Faculty Of Medicine Yamanashi Medical College
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Tsukahara Yoshiharu
Department Of Obstetrics & Gynecology Shinshu University School Of Medicine
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SIOZAWAL Isao
Department of Obst. Gynec., Faculty of Medicine, Shinshu Univ.
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Siozawal Isao
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine
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Noguchi Hiroshi
Department Of Architecture Faculty Of Engineering Chiba University
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Fukuta Toru
Department Of Obstetrics Alrd Gynecology Shinshu University School Of Medicine
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Noguchi Hiroshi
Department Of Obstetrics And Gynecology Faculty Of Medicale Shinshu University
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Noguchi Hiroshi
Department Of Anesthesiology And Acute Medicine Aichi Medical University
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Iwai Shoji
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine Matsumoto
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塚原 嘉治
Department of Obstetrics and Gynecology, Faculty of Medicale, Shinshu University
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NOGUCHI Hiroshi
Deparment of Mechanical Engineering, Kyushu University
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