A HISTOLOGICAL STUDY ON IMMUNE REACTION OF ADVANCED UTERlNE CERVICAL CARCINOMA WITH REGARD TO THE EFFECT OF A LOW-DOSE IRRADIATION AND PS-K
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概要
- 論文の詳細を見る
Histopathological studies were carried out to determine whether or not an immunological reaction was involved, in the treatment of cervical carcinoma. The following conclusions could be drawn from them. (1) A Iow-dose irradiation on the primary cancer-nest intensified the interstitial reaction. (2) When PS-K was administered after low-dose irradiation , the interstitial reaction was intensified more remarkably than with irradiation alone. Moreover, it was possible for PS-K administration to restore the responsiveness of lymph nodes which had been inhibited by the irradiation . (3) Some of the observed morphological changes suggested the local occurrence of an immunological reaction . The following findings could be pointed out : (a) In the primary lesion of the uterine cervix, exudative cells consisting mainly of lymphocytes, plasma cells, and macrophages formed a barrier-like layer surrounding the cancer-nest. Granuloma accompanied by foreign-body type giant cells were formed in the interstitial tissue. Moreover, Iymphoid tissues with a germinal center were formed. (b) In lymph nodes of the region involved, responsiveness was enhanced in the paracortical area, or a germinal center formed with its responsiveness enhanced. (4) There was a correlation between the degree of interstitial reaction of the primary lesion and the survival results of a follow-up survey. There was also a correlation between the degree of enlargement of lymph nodes and the survival results of this survey.
- 社団法人日本産科婦人科学会の論文
- 1981-02-01
著者
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ISHII Jun
Department of Molecular Science and Material Engineering, Graduate School of Science and Technology
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Ishii Jun
Department Of Obstetrics Alrd Gynecology Shinshu University School Of Medicine
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Fukuta Toru
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine
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Fukuta Toru
Department Of Obstetrics & Gynecology Shinshu University School Of Medicine
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TSUKAHARA Yoshiharu
Department of Obstetrics and Gynecology, Faculty of Medicine, Yamanashi Medical College
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Sakai Yoshikimi
Department Of Obstetrics Alrd Gynecology Shinshu University School Of Medicine
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SHIOZAWA Isao
Department of Obstetrics and Gynecology, Shinshu University School of Medicine
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IWAI Shoji
Department of Obstetrics and Gynecology, Shinshu University School of Medicine
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Tsukahara Yoshiharu
Department Of Obstetrics And Gynecology Yamanashi Medical College
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Tsukahara Yoshiharu
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine Matsumoto
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Tsukahara Yoshiharu
Department Of Obstetrics And Gynecology Faculty Of Medicine Yamanashi Medical College
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Tsukahara Yoshiharu
Department Of Obstetrics & Gynecology Shinshu University School Of Medicine
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Siozawal Isao
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine
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Ishii Jun
Department Of Biology Graduate School Of Science And Technology Kobe University
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Fukuta Toru
Department Of Obstetrics Alrd Gynecology Shinshu University School Of Medicine
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Iwai Shoji
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine Matsumoto
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