CLINICAL SIGNIFICANCE OF STATISTICAL DISCRIMINATION EMPLOYING SERUM TA-4, TPA, AND CEA LEVELS FOR UTERINE CERVICAL CANCER

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Synopsis The serum levels of TA.4, TPA, and CEA were measured simultaneously in 52 patients withuterine cervical cancer and 99 healthy females The findings were examined statistically by discrimlnantanalysis method The diagnostic usefulness of discriminant analysis employing the serum values for thesethree tunlor markers was studied for uterine cervical cancer and compared with the diagnostic efncacy usingeach tunlor marker aloneThe following results were obtained1 In the uterine cervical cancer patients, the frequencies of cases with the elevated sez levels were55 8% for TA-4, 46 2% for TPA, and 36 5% for CEA2 The functional formula, Z=1 8395 log TAI4+3 5314 log TPA +l 0130 log CEA-7 7352, wasobtained by the stepwise discriminant analysis method With the values obtained from this formula, 71 2%of patients with uterine cervical cancer were correctly classified in the uterine cervical cancer group3 In the uterine cervical cancer patients, the values obtaind from this formula increased according tothe progression of the clinical stage and renected the disappearance or persistence of tunlor lesions afterseveral therapiesFrom the above results, it was concluded that the discriminant analysis employing the serum values forthree tumor markers was extremely useful in determining complete remission of uterine cervical cancersafter several therapies, as well as for early diagnosis of the recurrences in uterine cervical cancer whichwere not detected by the cytologic smear examinations, compared with the measurement for each tumormarker alone This discriminant analysis, however, was less effective for early diagnosis of uterinecervical cancer than the cervical cytologic smear test
社団法人日本産科婦人科学会の論文
1986-10-01

CLINICAL SIGNIFICANCE OF STATISTICAL DISCRIMINATION EMPLOYING SERUM TA-4, TPA, AND CEA LEVELS FOR UTERINE CERVICAL CANCER

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