リンパ管腫の治療:外科切除,Bleomycin局注療法,OK-432局注療法の比較検討

概要

論文の詳細を見る
To determine a favorable treatment for lymphangiomas in children, we reviewed a 9-year (1980. 1-1988. 4) ex-perience with 39 lymphangiomas in children. The patiets were divided into 3 groups according to the treatment; Surgical Excision (N = 12), Intralesionl Bleomycin (BLM) Therapy (N = 5), and Intralesional OK-432 Therapy (N = 22). Excellent results including complete disappearance of the lesions without serious complications was noted in 4 of 12 treated by surgery, in one of 4 treated by BLM therapy, and in 14 of 22 treated by OK-432 therapy. Serious complications such as facial nerve palsy (1), ugly scars due to repeated excision (3) and testicular atrophy (1) were noted in surgically treated group. In the other groups, only a fever of 2-3 days' duration and local in-fammatory reaction of 3-5 days were noted. BLM therapy, however, was discontinued because in addition to low effective rate BLM was reported to have a serious side effects of pulumonary fibrosis. The results suggest that OK-432 therapy is effective for these lesions.
日本小児外科学会の論文
1989-04-20