膵管胆道合流異常モデルの研究 : II 胆汁内逆流膵蛋白分解酵素の活性化について

概要

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Using the canine models, the mode of activation of the pancreatic enzymes contained in the pancreatic juice was studied. Firstly, by an experiment of simple mixture of 1 ml of the fresh pancreatic juice and 15ml of the bile, it was observed that trypsin and elastase activities were completely negative after 3 hours' storage in the gallbladder and after 24 hours' incubation in 37℃in vitro, while the amylase value was preserved constantly around or over 10,000 IU/l. In the models of pancreatico-choledochostomy without enterokinase in the bile, the activation of trypsin and elastase was observed in all of 8 adult and 4 puppies except in one adult dog. The daily and hourly measurements of enzymic activity in the representative models revealed a constantly high level in amylase and simaltaneous activation of trypsin and elastase. The etiology of the disorders of hepatic and biliary systems in this anomaly was discussed in relation to the activation of the refluxed pancreatic enzymes into the biliary tract.
特定非営利活動法人日本小児外科学会の論文
1982-02-20