気管粘膜上皮の再生に関する実験的研究 : 特に表面微細構造の変化について

概要

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Seventeen mongrel puppies, weighing 1.5 kg to 2.0 kg, were lightly anesthetized with pentobarbital. Portex tube was inserted through vocal cord and stroked against the ventral surface of the trachea. Two control tracheas and nine injured tracheas were examined by scanning electron microscopy and light microscopy. Two tracheas were removed immediately after injury to examine the extent of injury. The other seven tracheas were removed three days, five days and eight days after injury. The tracheal lumen, at three days after injury, was covered with the rounded and elongated cells. At five days, the lumen was covered with elongated, flattened and polygonal epithelium, which surfaces were overlying with dotted microvilli and cilia-like projections. At eight days, the tracheal surface of the selected area showed regeneration of the celia, but dotted microvilli and cilia-like projections of varing size were seen in other areas, which showed the incomplete ciliary regeneration.
日本小児外科学会の論文