肝内転移をきたした肝芽腫の1手術治験例

概要

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A 1-year-2-month old male had two hepatic masses with elevation of serum alpha fetoprotein (AFP). Laparotomy disclosed a massive tumor (830g) in the lateral segment of the left lobe and a nodular one (50g) in the anterior segment of the right lobe. No other tumor could not be found out. A left segmentectomy and an wedge resection of the right anterior segment were performed. Pathological diagnosis was the well differentiated hepatoblastoma in both. The left tumor showed massive necrosis and was bordered with the fibrous septum, which was partly broken down by the tumor cells. In the right tumor, an intraportal tumor cell thrombosis was found and an active infiltration of the tumor cells was noticed into the liver tissue without fibrous capsule. Electron microscopical examinotion revealed many intracellular organs and remarkable microvilli between the tumor cells. Adjuvant chemotherapy was started on the 12 th day after the operation with FT207 supository 250mg/day for 10 days and was followed with 5-FU dry syrup 40mg/day for 2 years. AFP level was 59,360ng/ml on the day of operation and sharply decreased thereafter. The half life time was 53 hours. The patient has been doing well and is considered to be cured based on the level of AFP, laboratory tests and liver scintigram indicating no tumor at all for 2 years and 4 months.
日本小児外科学会の論文
1981-12-20