運動強度の差がammoniaおよびoxypurines動態に及ぼす影響

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We investigated the effect of the difference of exercise intensity on the changes in ammonia and oxypurines (hypoxanthine ・ xanthine). The subjects were 7 male university students who belonged to the Judo club. By using a bicycle ergometer with the same total work load (kpm), they performed following exercise : light exercise (27.1±0.8% HRmax), moderate exercise (72.6±2.5% HRmax) and exhaustive exercise. After light exercise, blood ammonia, serum oxypurines and urinary oxypurines excretion did not increase. Urinary uric acid excertion increased significantly, but serum uric acid decreased slightly. After moderate exercise, the significant increase was observed with blood ammonia (+35.3±5.9 μmol/l). Urinary oxypurines excretion also increased significantly, while serum oxypurines did not change. Also, serum uric acid rose slightly. After exhaustive exercise, the significant increase was observed with blood ammonia, sermn oxypurines and sermn uric acid. Each peak level and appearance time were +67.2±15.1 μmol/l after 3 min, +31.4±7.6 μmol/l after 30 min, 155.7±39.9 μmol/l after 1 hr of exercise, respectively. These results suggest that AMP deamination occur during moderate intensity, while remarkable production of oxypurines which lead the increase of serum uric acid occur in higher exercise intensity.
日本体力医学会の論文
1988-02-01