杜仲樹皮エキスのアナボリック効果に関する研究 : 去勢ラットにおける検討

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We evaluated the effect of Tu-Chung(Eucommia ulmoides OLIV.)extract on anaboliac action in castrated exercise and non-exercise rats in which the effects of male sex hormone from the testis were excluded. Castration was performed on 32male Wistar rats aged 4weeks. The rats were then divided into 4groups : a non-exercise group treated with Tu-Chung Extract(non Ex.Tu-chung G, n=8), on exercise group treated with the extract(Ex.Tu-chung G, n=8), a non-exercise control group not treated with the extract(non Ex.Cont.G, n=8), and an untreated exercise control group(Ex.Cont.G, n=8). The Tu-Chung extract was administered orally at a dose of 1g/kg body weight once daily for 4weeks. Distilled water was given by a similar method to the control groups. As the exercise load, the rats exercised on an animal treadmill at a starting speed of 20m/min with an increase of 10m/min every week for 30min without rest daily for 4weeks. The following results were obtained : 1.The relative weight of the adrenal gland(gland weight/100g body weight)after 4weeks was significantly higher in the non Ex.Tu-Chung G than in the non Ex.Cont. G(p<0.001)and in the Ex.Tu-Chung G than in the Ex.Cont.G or the non Ex.Cont.G(p<0.001each). 2.The relative weight of the kidneys(kidney weight/100g body weight)after 4weeks was significantly higher in the non Ex.Tu-Chung G than in the non Ex.Cont.G(p<0.001)and was slightly higher in the Ex.Tu-Chung G than in the Ex.Cont.G. 3.The relative weight of the musculus levator ani(muscle weight/100g body weight)after 4weeks was significantly higher in the non Ex.Tu-Chung G than in the non EX.Cont.G(p<0.001)and also in the Ex.Tu-Chung G than in the Ex.Cont.G(p<0.001). 4.The 17-KS level in a 24h urine sample after 4weeks was significantly higher in the non Ex.Tu-Chung G than in the non Ex.Cont.G or the Ex.Tu-Chung G(p<0.001 each)and also in the Ex.Tu-Chung G than in the Ex.Cont.G(p<0.001). 5.The total urinary nitrogen level after 4weeks was significantly lower in the non Ex.Tu-Chung G than in the non Ex.Cont.G(p<0.001)or the exercise group treated with the extract(p<0.05)and also in the Ex.Tu-Chung G than in the Ex.Cont.G(p<0.05). These results suggest that administration of Tu-Chung extract significantly increases the relative weight of the adrenal gland, enhances androgen secretion from the reticular layer of the adrenal cortex, and promotes protein anabolic action in castrated rats. In addition, this extract appears to increase the adaptation ability of the adrenal cortex to the stress caused by exercise.
1997-06-01

杜仲樹皮エキスのアナボリック効果に関する研究 : 去勢ラットにおける検討

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