杜仲樹皮エキスの投与が運動ラットの性腺-副腎系に及ぼす影響

概要

論文の詳細を見る
This sutdy examined the secretion capacity of the gonadal and adrenal cortex systems and the morphology of the adreal cortex in male rats treated with Tu-chung(Eucommia ulmoides OLTV)extract, the main component of Tu-chung extract, geniposede, or both agents during exercise load testing. Twenty-four 4-week-old male Wistar rats were used. The rats were divided into four groups : those treated with Tu-chung extract and geniposide(n=7), those treated with Tu-chung extract(n=6), those treated with geniposide(n=7)and a control group treated with distilled water. The dose of each agent was 0.1ml/100g body weight. The agents were administered orally for 25days. For the exercise load test, a treadmill for small animals was used, with a tilting angle set at 0. Exercise load testing was performed for 30min(2-min warm up and 28-men running)daily for 25days. The running speed was 20m/min for the first 5days, and then increased by 5m/min every 5days.The following results were obtained. 1.The relative weight of the adrenal gland(gland weight/100g body weight)in the group treated with Tu-chung extract and geniposide was significantly higher than that in the group treated with geniposide or the control group(p<0.01). The relative weight of the adrenal gland in the group treated with Tu-chung extract was significantly higher than that in the group treated with geniposide or the control group(p<0.01, p<0.001). Furthermore, the relative gland weight in the group treated with geniposide was significantly higher than that in the sontrol group(p<0.05). 2.In the group treated with Tu-chung extract and geniposide, the group treated with Tu-chung extract and the group treated with geniposede, the relative gland weight of the testis(testis weight/100g body weight)was significantly higher than that in the control group(p<0.001). Howecer, there were no significant differences among the three groups. 3.The 24-h urinary excretion of 17-ketosteroid(17-KS)in the group treated with Tu-chung extract and geniposide was significantly higher than that in the group treated with Tu-chung extract, the group treated with geniposide or the control group(p<0.01, p<0.01, p<0.001). In the group treated with geniposide, the 24-h urinary excretion of 17-KS was significantly higher than that in the control group(p<0.05). 4.In the three groups treated with Tu-chung extract and/or geniposide, serum testosterone levels were significantly higher than those in the control group(p<0.001, p0.05, p<0.05). 5.Concerning the morphology of the adrenal cortex, the thickness of the reticular layer of the adrenal cortex was most markedly increased in the group treated with Tu=chung extract and geniposide, followed in order by te group treated with Tu=chung extract, the group treated with geniposide and the control group. Administration of Tu-chung extract and the main component of Tu-chung extract, geniposide, during exercise load testing significantly increased the weights of the adrenal gland and testis, and promoted testosterone secretion in the adrenal cortex reticular layer and testis. These findings suggest that geniposide plays an important role in the pharmacological action of Tu-chung.
1997-06-01

杜仲樹皮エキスの投与が運動ラットの性腺-副腎系に及ぼす影響

スポンサーリンク

概要

著者

関連論文

スポンサーリンク