植物ホルモン類の精密合成によるプローブ化とその応用に関する研究

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In the last decade, evoiutional development of molecular biology and moiecular genetics has brought about noticeable advance in research on plant hormoncs at a molecular level: there has been a rapid about noticeable advance in research on plant hormoncs at a molecular level: there has been a rapid these investigations, the functional probes of plant hormones have been playing an important role, including i) compound libraries consisting of biosynthetic intermediates and metabolites, ii) isotopically labeled compounds, iii) hybrid molecules carrying proper functional molecules on plant hormones, iv) antagonists of biosynthetic enzymes, and v) agonists and antagonists of hormones. In this work, expecting the specified function to each probe, we aimed to assemble various kinds of molecular probes of jasmonates, gibberellins and brassinosteroids, based on fine and precision synthetic chemistry. For this purpose, we developed the new strategies and reactions for refining the synthetic routes to the targeted molecules and elaborated the structures of the targeted molecules by molecular design in order to introduce the new functions and distinguished features to the hormones. For molecular design, the data on the structure-activity relationships of each hormone were accumulated by bioassay of most of synthetic compounds, which was essential especially for designing the molecular probes iii)-v) mentioned above. In the present lecture, the outline will be discussed by some selected topics focusing on assembling the probes along with their achievements in plant science.
植物化学調節学会の論文
2001-10-09

植物ホルモン類の精密合成によるプローブ化とその応用に関する研究

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