ACUTE TOXICITY OF CHLOROPEPTIDE, A HEPATOTOXIC METABOLITE OF PENICILLIUM ISLANDICUM SOPP
スポンサーリンク
概要
- 論文の詳細を見る
Chlorine-containing cyclic pentapeptide (Cl-peptide) is one of the hepatotoxic and hepatocarcinogenic metabolites of Penicillium islandicum Sopp. The sc LD_<50> values of Cl-peptide for mice, rats and guinea-pigs were all in the range of 0.5 mg/kg, while the po LD_<50> values for mice and rats were around 5mg/kg. The newborn mice were less susceptible than the adults. The acutely intoxicated mice and rats showed a marked elevation of serum transaminases and a transient increment followed by a marked decline of blood glucose level. The liver of animals pretreated with the toxin showed marked declines of glycogen and microsomal protein and an increase of cyclic AMP content. Tracer experiments revealed a preferencial accumulation of the toxin in the liver of mice and an excretion through feces. Correlation between the hepatotoxicity and the hepato-accumulation of the cyclic peptide was discussed.
- 日本トキシコロジー学会の論文
- 1977-10-15
著者
-
ITO Teruo
Department of Radiation Oncology, The Cancer Institute, Ariake Hospital of Japanese Foundation for C
-
Ito Teruo
Department Of Toxicology And Microbial Chemistry Faculty Of Pharmaceutical Sciences
-
UENO Yoshio
Department of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science Univer
-
Ito Teruo
Department Of Cardiology Nagoya Daini Red Cross Hospital
-
Ito Teruo
Laboratory Of Microbial Chemistry Faculty Of Pharmaceutical Sciences Tokyo University
-
UENO Ikuko
Department of Cancer Susceptibility, Institute of Medical Sciences, Tokyo University
-
HASHIMOTO Naokazu
Department of Microbial Chemistry and Toxicology, Faculty of Pharmaceutical Sciences, Tokyo Universi
-
Hashimoto Naokazu
Department Of Microbial Chemistry And Toxicology Faculty Of Pharmaceutical Sciences Tokyo University
-
Ueno Ikuko
Department Of Cancer Susceptibility Institute Of Medical Sciences Tokyo University
-
Ueno Yoshio
Department Of Toxicology And Microbial Chemistry Faculty Of Pharmaceutical Sciences
-
Ueno Yoshio
Laboratory Of Microbial Chemistry Faculty Of Pharmaceutical Sciences Tokyo University
-
Ueno Yoshio
Department Of Applied Chemistry Nagoya Institute Of Technology
関連論文
- Dosimetric consideration of individual ^I source strength measurement and a large-scale comparison of that measured with a nominal value in permanent prostate implant brachytherapy
- FINE STRUCTURAL CHANGES AND APOTOTIC CELL DEATH BY T-2 MYCOTOXIN
- Hemodynamic effects of pacing therapy on LV systolic function in patients with heart failure (HF), intraventricular conduction delay (IVCD) and atrial fibrillation
- TOXICOLOGICAL STUDIES ON TRIBUTYL PHOSPHATE. (I) ACUTE AND SUBACUTE TOXICITIES
- CYTOTOXICITY OF CHLOROPEPTIDE IN ISOLATED HEPATOCYTES AND ITS INACTIVATION BY MICROSOMES
- EFFECTS OF CHLOROPEPTIDE ON LIVER COMPONENTS AND SERUM ENZYME ACTIVITIES IN MICE
- Radiolarian Biostratigraphic Study of the Shimanto Group in the Nanto-Nansei Area, Mie Prefecture, Kii Peninsula, Central Japan
- MICROSOMAL INJURY IN THE LIVER OF RATS TREATED WITH CARBON TETRACHLORIDE
- 205. Studies on Microsomal injury in Liver (I) : CCl_4-induced changes of polysomal structure, protein synthesis and related enzymes in rat liver (The Second Meeting for the Study of Toxic Effect)
- RESEARCHES ON THE in vivo BINDING OF AFLATOXIN B_1 TO DNA IN ISOLATED RAT LIVER NUCLEI (The 6th Meeting for the Study of Toxic Effect)
- Type A Behavior Pattern as a Risk Factor for Coronary Heart Diseases: 53th Annual Scientific Session of the Japanese Circulation Society
- CHRONIC TOXICITY AND HEPATOCARCINOGENICITY OF (+) RUGULOSIN, AN ANTHRAQUINOID MYCOTOXIN FROM PENICILLIUM SPECIES : PRELIMINARY SURVEYS IN MICE.
- CHRONIC TOXICITY OF POLYCHLORONAPHTHALENE IN MICE (The 6th Meeting for the Study of Toxic Effect)
- TOXICOLOGICAL APPROACHES TO THE METABOLITES OF FUSARIA. XIII. HEMATOLOGICAL CHANGES IN MICE BY A SINGLE AND REPEATED ADMINISTRATIONS OF TRICHOTHECENES
- ACUTE AND SUBACUTE TOXICITIES OF POLYCHLORONAPHTHALENE IN MICE (The 5th Meeting for the Study of Toxic Effect)
- IMPAIRMENTS OF GLYCOGEN AND DRUG METADOLISMS BY CHLOROPEPTIDE, A HEPATOTOXIC MYCOTOXIN OF PENICILLIUM ISLANDICUM SOPP
- ACUTE TOXICITY OF CHLOROPEPTIDE, A HEPATOTOXIC METABOLITE OF PENICILLIUM ISLANDICUM SOPP
- INTERACTION BETWEEN QUERCETIN AND SUPEROXIDE RADICALS. REDUCTION OF THE QUERCETIN MUTAGENICITY
- EFFECTS OF NIVALENOL ON THE BONE MARROW IN MICE
- Transport of ochratoxin A by renal multispecific organic anion transporter 1 and its effect on cell proliferation
- RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ACCELERATES REGENERATION AFTER T-2 TOXIN-INDUCED HEMOPOIETIC INJURY AND LESSENS LETHALITY IN MICE
- PB184 FREE-RADICAL ALLYLATION OF α-SELENOCARBONYL COMPOUNDS : NEW SYNTHESIS OF PROSTAGLANDIN DERIVATIVE
- SIMILARITY OF CHLOROPEPTIDE TO PHALLOIDIN IN TOXICITY TO ISOLATED HAPATOCYTES
- A New ELISA for Survey of Microcystins in Environmental Water using Anti-idiotype Monoclonal Antibody against Anti-microcystin Antibody
- Development of Sandwich Immunoassay for Microcystins, a Natural Contaminant in Environmental Water : An Assay Based on Anti-Immune Complex Antibodies (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Determination of Microcystin in Environmental Water by Highly Sensitive Immunoassay (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- TOXICOLOGICAL APPROACHES TO THE TOXIC METABOLITES OF FUSARIA VIII. ACUTE AND SUBACUTE TOXICITIES OF T-2 TOXIN IN CATS
- Bond-Specific Chemical Cleavages of Peptides and Proteins with Perfluoric Acid Vapors: Novel Peptide Bond Cleavages of Glycyl-Threonine, the Amino Side of Serine Residues and the Carboxyl Side of Aspartic Acid Residues
- MODE OF ACTION AND METABOLISM OF ZEARALENONE, AN ESTROGENIC MYCOTOXIN
- OVEREXPRESSION OF C-MYC GENE IS REQUIRED FOR TAMOXIFEN-ELICITED APOPTOSIS IN AFLATOXIN B_1-INDUCED RAT HEPATOMA CELLS
- A New Fragmentation Reaction of γ-Oxosulfonium Methylides
- Radical cyclization to seleno-substituted thiahomoprotoadamantanone and its unexpected conversion to the vinyl selenide.
- A convenient synthesis of naphtho[1,2-b]furans.
- Liquid-phase oxidation of anthracene in acetic acid by copper(II) chloro complexes.
- Liquid-phase oxidation of anthracene in acetic acid by use of copper(II) chlorocomplexes. II. Kinetic study.
- Selenation of 1,5-Naphthoquinones:Novel Synthesis of Naphthopyridoselenazines.
- The carbon-13 NMR spectra and electronic structure of 3H-phenoxazin-3-ones.
- Synthesis and tautomerism of 1,5-bis(alkylamino)-4H-benzo(a)phenothiazin-4-ones.