院内臨床分離菌に対するクロルヘキシジンの殺菌効果

概要

論文の詳細を見る
Bactericidal effect of chlorhexidine (CH) on clinically isolated bacterial strains was examined. Twenty-one isolates out of 61 (40 from inpatients samples and 21 from hospital environment) survived after the treatment of 0.5% chlorhexidine for 10 sec. They were P. cepacia, P. aeruginosa, Enterobacter, Flavobacterium and A. calcoaceticus. Most of them, except for P. cepacia were killed by the treatment of 0.1% CH for 5 min. P. cepacia was killed by 0.5% CH for 60 sec treatment. MIC of CH for those strains showed that chlorhexidine-resistant strain did not exist in the strains isolated from clinical material in the hospital where CH was routinely used as a general disinfectant. For a rapid and handy examination for the detection of disinfectant-resistant bacteria, oxymeter was applied. Oxygen consumption of bacteria was inhibited at the same concentration of MIC which was examined by a conventional method, indicating that the method was applicable to a routine use. Discussion was made on a possible mechanism of chlorhexidine resistant.
日本医療薬学会の論文
1990-02-20