院内製剤の品質管理 : メチルプレドニゾロンゼリーの安定性および放出試験

概要

論文の詳細を見る
Methylprednisolone (MP) jelly was prepared for local application for treatment of the proctitis, which was sometimes caused by the radiation therapy for cervical cancer of the uterus. The stability and the release of the MP from the MP jelly were investigated using the highperformance liquid chromatography (HPLC). The results were as follows: 1) The MP jelly was sufficiently stable at 4℃ for 14 days after preparation, while at room temperature the amount of MP in the jelly was decreased to 74% after 14 days. 2) The 50% release of MP from MP jelly required 180 min under the stationary condition; however, under the stirring condition the 50% and 100% release required 45 min and 180 min, respectively. This preparation showed a good clinical effect.
日本医療薬学会の論文
1986-02-20