ジゴキシンの製剤間のバイオアベイラビリティについて

概要

論文の詳細を見る
The Bioavailability of digoxin in the commercial tablet and powder was compared. At first, the concentrations of digoxin in plasma and saliva of 5 healthy volunteers were determined by radioimmunoassay following oral administration of digoxin. The bioavailability of the tablet was found to be higher than that of the powder. Secondly, the dissolution rates of digoxin in tablet and powder dissolved in 1st fluid (J.P.IX) at 37°were measured according to U.S.P.XIX. Then, the tablet was found to have a higher dissolution rate than the powder. Therefore, the rate of absorption is considered to be correlated with the dissolution rate. The salivary digoxin measurement may be expected to be a monitoring factor since the digoxin concentration in saliva is correlated with that in plasma.
日本医療薬学会の論文
1981-08-20