Ameliorated Outcome of Subarachnoid Hemorrhage Patients Treated with Reduced Form Glutathione

概要

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This study was designed to investigate the effects of glutathione (GSH) on delayed vasospasm and the outcome of subarachnoid hemorrhage (SAH) patients. Seventy-seven SAH patients who were admitted to 4 hospitals and operated on within 72 h after SAH, were injected intravenously with GSH (2.4 g/day) every 6 h for 14 days. Seventy SAH patients who were not treated with GSH in the same period were selected as the control group. Patient background, the outcome at 3 months after SAH according to the Glasgow Outcome Scale and the occurrence of symptomatic vasospasm were investigated. There were no statistically significant differences in patient backgrounds between the 2 groups. Regarding patient outcome, 57 patients (74%) showed good recovery, 8 (10%) were moderately disabled, 9 (12%) were severely disabled, 2 (3%) were in vegetative survival and 1 (1%) died in the GSH group, versus 39 (56%), 9 (13%), 15 (21%), 3 (4%) and 4 (6%) in the control group, respectively. These overall outcomes in the GSH group were significantly better than those in the control group (P < 0.05). In the GSH group, 31 patients (40%) showed symptomatic vasospasm, significantly lower than 46 (66%) in the control group (P < 0.01). Administration of GSH could be a good treatment for SAH patients.
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