Effects of Bromocriptine and Radiation on the Size and Activity of Estrogen-induced Rat Prolactinoms

概要

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Estrogen-induced rat prolactinomas were produced after seven weekly injections of 2.5 mg of estradiol valerate. The rats were treated with various combinations of therapeutic agents. They were divided into four groups including the bromocriptine (CB) treated group, irradiated group, combined CB and radiation treated group, and finally the control group. Serum concentrations of prolactin and weights of tumors containing pituitary tissues were measured and statistically compared.<BR> The suppressing effect of CB against prolactinomas was well demonstrated in their hormonal activities. But it alone was not effective in reducing the size of prolactinomas. Concerning irradiation, on the 17th day it alone was not effective in reducing hormonal activities of rat prolactinomas. In the chronic stage, on the 30th day radiation alone was effective in reducing hormonal activity. Throughout the experiment CB was more potent than radiation in reducing hormonal activity. Concerning the size reducing effect, combined use of CB with radiation was significantly effective. If CB is not sufficient in reducing the size and hormonal activity of human prolactinoma, its combined use with radiation may be suggested.
日本脳神経外科学会の論文
1985-01-15