経皮吸収型虚血性心疾患治療薬3製剤間における副作用としての皮膚刺激性の臨床および基礎的検討

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The side effects of nitrate patch preparations for ischemic heart disease were evaluated in both inpatients and volunteers. Therefore, a removal test of hony cells. adhesion test and down rolling ball (tack) test were all studied to clarify the pharmaceutical characteristics of these preparations. As a result. the score of the skin irritation of the NitrodermTTS^<[O!R]> preparation was significantly higher than that for the other two preparations (Antup^<[O!R]> and Frandol tape S^<[O!R]> preparation). No correlations were observed between skin irritation and the amount of homy cells removed by the NitrodermTTS^<[O!R]>. The Antupn^<[O!R]> preparation was the strongest for the adhesion test. How-ever. the NitrodermTTS^<[O!R]>) preparation was the strongest for the tack test. These findings suggest that one reason for the increased skin irritation of NitrodermTTS^<[O!R]> may be due to its high degree tack influence.
1999-10-10