一酸化窒素から亜酸化窒素への変換 : 一酸化窒素還元酵素の構造と機能

概要

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From chemical point of view, the NO reduction to N_2O is one of the most attractive subjects, since it contains the N-O bond cleavage and N-N bond formation with aid of two electrons and two protons. Nitric oxide reductase (NOR) is a key enzyme for this reaction in biological denitrification processes. Two types of NORs have been isolated from some microorganisms and characterized ; one is a soluble cytochrome P450-type enzyme from fungi, whereas the other is a membrane-bound cytochrome fee-type complex from denitrifying bacteria. These NORs effectively catalyze the NO reduction in a quite different mechanism. Here we summarize the current results in the mechanistic study of NO reduction reaction conducted by each enzyme, and discuss their molecular mechanism based on their structural and functional information.
日本生物物理学会の論文
2004-07-25