1^H-NMRよりみた生体組織内の水の特性 : 基礎研究から臨床医学応用へ

概要

論文の詳細を見る
It is well-known that water plays a major role in a large number of biological processes in living systems and it is also commonly believed that the properties of water near interfaces are quite different from those of the bulk water by the interaction between. water and interfaces. Living systems, such as cells and tissues are very rich in such interfaces due to the existence of the cellular cytoskeleton. While conducting 360 MHz H-NMR studies on cross-relaxation phenomena in protein gel and solution, and in rat normal and hepatocellular tumor, we found that intermolecular cross-relaxation times (T_<IS>) from irradiated protein protons to water protons are a sensitive parameter of water-macromolecule interaction and that T_<Is> imaging could provide new information on the difference in the interaction of water with the macromolecule in vivo.
日本生物物理学会の論文
1994-03-25