神経性食欲不振症と細胞性免疫機能

概要

論文の詳細を見る
Peripheral blood lymphocyte subset numbers and percents, natural killer cell (NK) activity and serum interleukin 2 (IL 2) were studied by comparing patients with anorexia nervosa and bulimia nervosa to normal control subjects. While there were no significant difference in CD 2,CD 3,CD 4,nor CD 8 positive cells on percent basis among these subjects, patients with anorexia nervosa exhibited significant reductions in CD 2,CD 3,CD 4,CD 8,and CD 19 positive cell numbers and NK activity. On the other hand, patients with bulimia nervosa showed normal numbers of lymphocyte subsets except for CD 19 positive cells and normal NK activity. These abnormalities described above in patients with anorexia nervosa did not change after nearly restoration of body weight accompanied with returned normal levels of serum T 3 and cortisol. On the other hand, serum IL 2 Ievels were higher in patients with anorexia nervosa compared to those in normal control subjects. These results suggest that cellular mediated immunity in patients with anorexia nervosa might be reserved in spite of the reductions of T and B Iymphocytes and NK activity. However, it might take a long time to become normalization of these abnormalities such as the reductions of T and B Iymphocytes and NK activity. Moreover, these abnormalities were not resulted from high serum cortisol levels.
日本心身医学会の論文
1993-08-01