うつ病の断眠療法と血中副腎皮質ホルモンの日内リズム(心身症における情動と内分泌8第5回日本精神身体医学会総会シンポジウム)

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Pflug first reported sleep deprivation therapy of depression in 1971. We have been interested in this therpeutic method. Thirty eight depressive patients were treated with sleep deprivation in our hospital and showed considerable improvements. But the mechanism which underlies the effect of sleep deprivation remains obscure. Depression is frequently associated with sleep disturbances and circadian variations of mood and it suggests that there may be some abnormality of physiological rhythm. So it is presumed that sleep deprivation affects the physiological rhythm in depressive patinets. As a physiological rhythm in the organismus, a circadian rhythm of plasma corticosteroids has been well established.In this report, to determine the influence of sleep deprivation on the physiological rhythm, the pattern of the circadian variation of plasma cortisol levels was studied in 18 depressive patients who were deprived of one night sleep. Plasma cortisol was estimated in 20 studies of 18 depressive patients and 10 controls, who were also deprived of sleep together with patients, at 8. 00,12. 00,16. 00,20. 00 of the day (1 st day) and at 0. 00,4. 00,8. 00,12. 00,16. 00,20,00 of the following day (2 nd day). Thus the mean values of plasma cortisol levels were compared.Results were as follows ; The mean values of cortisol levels of depressive patients were not different from those of controls in 1 st day except at 20. 00. In the 2 nd day, depressive patients showed higher mean values than controls at all sampling times. The data suggests that sleep deprivation causes a different effect on the physiological rhythm of depressive patients from controls.
日本心身医学会の論文
1975-02-01

うつ病の断眠療法と血中副腎皮質ホルモンの日内リズム(心身症における情動と内分泌8第5回日本精神身体医学会総会シンポジウム)

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