Application of Collagen Scaffolds for Hepatic Stem-Like Cell Transplantation
スポンサーリンク
概要
- 論文の詳細を見る
Tissue engineering using somatic stem cells is a new and exciting techniquewhich has the potential to facilitate tissue reconstruction. Recent studies on tissueengineering have indicated advantages in using collagen matrices to restitute the structureof an organ. Here we have demonstrated the efficacy of transplantation of hepaticstem-like (HSL) cells, a previously established liver epithelial cell line with potential fordifferentiation, using type I collagen sponge. To this end, HSL cells were cultured andtransplanted into Nagase's analbuminemic rat with spongy type I collagen matrices.Consequently, HSL was able to express both albumin and TAT after the culture incollagen sponge. In addition, the levels of serum albumin in recipient rats were foundto increase up to 1.5 fold relative to controls after transplantation. These findingssuggest that HSL cells are able to differentiate into functional hepatocytes, and thatbiodegradable collagen sponge may enhance hepatic differentiation of HSL cells byproviding an appropriate microenvironment.
- 秋田大学の論文
著者
-
UENO Yasuharu
Department of Biochemistry, Akita University School of Medicine
-
Watanabe Go
Department Of Biochemistry Akita University Graduate School Of Medicine
-
Sugiyama Toshihiro
Department Of Biochemistry Akita University Graduate School Of Medicine
-
ISHIKAWA Kiyoshi
Department of Biochemistry, Akita University School of Medicine
-
YOSHIKAWA Kiwamu
Department of Biochemistry, Akita University School of Medicine
-
KAMEDA Takashi
Department of Biochemistry, Akita University School of Medicine
関連論文
- A Case with Prolactinoma Treated with Pergolide and Its Histology
- Videothoracoscopic Surgery for Thoracic Neurogenic Tumors : A 7-Year Experience
- Endobronchial Metastasis from Renal Cell Carcinoma : Report of a Case
- Low-Density Lipoprotein Particle Diameter in Normal Pregnancy and Preeclampsia
- REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells
- Soluble EMMPRIN (extra-cellular matrix metalloproteinase inducer) stimulates the migration of HEp-2 human laryngeal carcinoma cells, accompanied by increased MMP-2 production in fibroblasts
- Copper-transporting P-Type Adenosine Triphosphatase (ATP7B) Is Expressed in Human Breast Carcinoma
- Analysis of cartilage maturation using micromass cultures of primary chondrocytes
- Application of efficient and specific gene transfer systems and organ culture techniques for the elucidation of mechanisms of epithelial-mesenchymal interaction in the developing gut
- Transplantation of rat hepatic stem-like (HSL) cells with collagen matrices
- Application of Collagen Scaffolds for Hepatic Stem-Like Cell Transplantation
- Simaomicin α, a polycyclic xanthone, induces G_1 arrest with suppression of retinoblastoma protein phosphorylation
- Inverse Correlation between the Changes of Lumbar Bone Mineral Density and Serum Undercarboxylated Osteocalcin after Vitamin K_2 (Menatetrenone) Treatment in Children Treated with Glucocorticoid and Alfacalcidol
- Possible involvement of vitamin D receptor gene polymorphism in male patients with ossification of spinal ligaments
- Improvement of periarticular osteoporosis in postmenopausal women with rheumatoid arthritis by β-alanyl-L-histidinato zinc: a pilot study
- Menatetrenone plus alfacalcidol treatment for bone problems in eight children with skeletal unloading
- Vitamin K may improve bone disorder in long-term glucocorticoid-treated children with vitamin D supplementation
- β-Alanyl-L-histidinato zinc may improve periarticular osteoporosis in rheumatoid arthritis patients
- Locally infused insulin-like growth factor-I into femur stimulates gene expression and bone turnover in old rats
- Growth and bone mineral density in a child with X-linked hypophosphatemic rickets: Early response treatment
- STIMULATORY EFFECT OF CYTOCHROME ___ INDUCED BY P___-NITROANISOLE AND MALOTILATE ON HEPATIC MICROSOMAL DRUG HYDROXYLATIONS
- THE IMMUNOSUPPRESSION OF HUMAN T CELL PROLIFERATION PATHWAYS BY A CHORIOCARCINOMA-CELL-DERIVED FACTOR
- SELECTIVE ACTIVATION AND PROLIFERATION OF CORD T CELLS WITH TUMOR PROMOTER AND CALCIUM-IONOPHORE
- LOW SUSCEPTIBILITY OF CHORIOCARCINOMA CELL LINES TO LYMPHOKINE-ACTIVATED KILLER (LAK) CELLS
- AN ELISA FOR ANTISPERM ANTIBODIES
- Expression of Vascular Endothelial Growth Factor Gene and Its Receptor (flt-1) Gene in Urinary Bladder Cancer
- Purification and Characterization of a Novel Prolyl Aminopeptidase from Maitake (Grifola frondosa)
- Effects of Nucleotides on the Interaction of Renin with GlcNAc 2-Epimerase (Renin Binding Protein, RnBP)
- Paenidase, a Novel D-Aspartyl Endopeptidase from Paenibacillus sp. B38 : Purification and Substrate Specificity
- INTERACTIONS OF VASCULAR ENDOTHELIAL CELLS AND SMOOTH MUSCLERELATED CELLS WITH TYPE IV COLLAGEN
- Serum-dependent Secretion of Nondisulfide-bonded and Unfolded Type IV Collagen α Chains by Cultured Fetal Lung Fibroblasts
- Ethanol Fermentation System Combined with Membrane Separator of Pervaporation.
- Synergistic Effect on Reactive Oxygen Scavenging Activity of Fermented Okara and Banana by XYZ System
- RECONSTITUTION OF A DRUG METABOLIZING SYSTEM CONTAINING CYANIDE-SENSITIVE CYTOCHROME P-450
- PROPERTIES OF HIGHLY PURIFIED FORMS OF LIVER MICROSOMAL CYTOCHROMES P-450_ AND P-448 FROM UNTREATED RABBITS
- KINETIC STUDIES ON THE P-NITROANISOLE O-DEMETHYLATION CATALYZED BY CYTOCHROME P-45O_ WITH A HIGH AFFINITY FOR CYTOCHROME b_5
- MULTIPLICITY OF CYTOCHROME P-450 AND ITS SUBSTRATE-SPECIFICITY IN THE METABOLISM OF XENOBIOTICS (The 6th Meeting for the Study of Toxic Effect)
- EXPRESSION OF FOS AND JUN FAMILY PROTEINS IN CULTURED CHICKEN CHONDROCYTES.
- Leydig Cells Undergoing Apoptosis in the Perinatal Rat Testis
- Novel Approach for a Pulmonary Bronchogenic Cyst : A Report of a Case
- Phosphate Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts
- HETEROGENEOUS EXPRESSION OF Leu3/T4 ANTIGEN ON CORD T CELLS
- Quantitative Detection of Apoptotic Thymocytes in Low-dose X-irradiated Mice by an Anti-single-stranded DNA Antibody
- Antibody against Single-Stranded DNA Useful for Detecting Apoptotic Cells Recognizes Hexadeoxynucleotides with Various Base Sequences^1
- Structures of Multilayered Thin Films of Long-Chain Molecules : X-ray Scattering Study
- Structure of Normal Alkane Evaporated Films : Molecular Orientation
- The Fragment of Complement 3a Lacking the Primary 9 Amino Acids Induces Promoting Activity on Mouse Voluntary Running
- Secretion of Non-Helical Collagenous Polypeptides of α1(IV) and α2(IV) Chains upon Depletion of Ascorbate by Cultured Human Cells^1
- Reconstitution of hepatic tissue architectures from fetal liver cells obtained from a three-dimensional culture with a rotating wall vessel bioreactor(CELL AND TISSUE ENGINEERING)
- Pharmacological Mechanism in Slip-Down Behavior of Mice
- Effects of skeletal loading on bone mass and compensation mechanism in bone : a new insight into the "mechanostat" theory
- Changes in bone biochemical markers after high-dose cerivastatin treatment in a woman with osteogenesis imperfecta
- Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K
- A novel monoclonal antibody identified hepatic stem-like cells in rats
- The Long-Evans Cinnamon rat: An animal model for Wilson's disease
- Humoral Ga1NAcα1-3Ga1NAc-Lipid Reactivity of Humans in Hypomanic State
- Glycoside in Schizophrenic Patients Sera Affects Behavior of Mouse Forced Swimming
- Involvement of interleukin-6 and prostaglandin E_2 in periarticular osteoporosis of postmenopausal women with rheumatoid arthritis
- The Effect of Globopentaosylceramide on a Depression Model, Mouse Forced Swimming
- Antiproliferative and Proapoptotic Effects of Tocopherol and Tocol on Activated Hepatic Stellate Cells
- Electric toothbrushes induce electric current in fixed dental appliances by creating magnetic fields
- Intraoral conversion of occlusal force to electricity and magnetism by biting of piezoelectric elements
- Ultrafast Single-Shot Optical Oscilloscope based on Time-to-Space Conversion due to Temporal and Spatial Walk-Off Effects in Nonlinear Mixing Crystal
- Anti-Melanogenesis Effect of Glechoma hederacea L. Extract on B16-Murine Melanoma Cells
- Magnetic fields from electric toothbrushes promote corrosion in orthodontic stainless steel appliances but not in titanium appliances
- Differential Increases in the Expression of Intermediate Filament Proteins and Concomitant Morphological Changes of Transdifferentiating Rat Hepatic Stellate Cells Observed In Vitro
- Characterization of Glycosylphosphatidylinositol-Anchored Ceruloplasmin Enriched in the Apical Plasma Membrane of Rat Hepatocytes