<原著>麻酔剤(ペントバルビタール)の温熱効果に対する影響

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We evaluated the influence of the combined use of pentobarbital (PENT), an anesthetic, on hyperthermic effects. C_3H mice bearing a subcutaneous SCC-VII tumor in the thigh (5 Weeks, 23-25 g, female) were treated by hyperthermia using a hot water thermostat (43℃ and 44℃). Tissue blood flow before heating was measured using a laser doppler flowmeter. The respiratory rate was measured based on movements of small size magnet attached to the abdomen using a magnet sensor. After PENT administration (50 mg/kg, IP), the blood flow in the normal area temporarily increased, while that in the tumor remained low. The mean respiratory rate before PENT administration was 254/min but that after PENT administration was 204/min, showing about a 2O% decrease. The days required for the tumor to double in size after hyperthermia were 3.77 days in the untreated control group. 4.57 days in the group treated by 43℃ hyperthermia (30 minutes) in combination with PENT administration, 6.00 days in group treated by 43℃ hyperthermia (30 minutes) alone, and 8.68 days in the group treated by 44℃ hyperthermia (30 minutes) alone. We speculated that blood flow decreases after PENT administration (susceptibility to hyperthermic action due to low thermodiffusion), and a decrease in the respiratory rate and a resulting decrease in the blood oxygen partial pressure reduce the tumor pH, enhancing hyperthermic effects. However, the tumor grew more rapidly in the group treated by hyperthermia in combination with PENT than in the group treated by hyperthermia alone. These results suggest that PENT clinically has protective effects on thermal injury. Therefore, caution is necessary when the same types of anesthetics as PENT are clinically used.
鈴鹿医療科学大学の論文
1998-03-30

<原著>麻酔剤(ペントバルビタール)の温熱効果に対する影響

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