<総説>悪性腫瘍に対する温熱治療の生物学的根拠

概要

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Historical reviews of the eary clinical use of hyperthermia can be found in several excellent review articles (Dewey et al., 1977). Hyperthermia shows a family of survival curves for cell exposed, for various periods of time, to a range of temperatures from 41.5 to 46.5℃. Also hyperthermia has special characteistic as follows : (a) Hypoxia does not protect cells from damage by heat. (b) Nutritionally deprived cells, which probably exist in many tumors, are more sensitive to heat than adequately fed cells. (c) Heat may be more damaging at low pH, and it is commonly thought that tumors tend to be acidic due to anaerobic metabolism. (d) The neoplastic cells may be intrinsically more sensitive to heat than normal calls. (e) Heat is more damaging to cells in the DNA synthetic phase of the mitotic cycle, when X-rays are the least effective conditions. (f) Heat prevents the repair of potentially lethal damage (PLD) from X-rays. The experimental data serve to emphasize the need for uniform temperature control and precise temperature measurments when hyperthermia is applied in clinical setting. Consequently, there is no question that heat kills tumor tissues more than normal tissues.
鈴鹿医療科学大学の論文
1996-03-30