拡大内視鏡を用いたAberrant crypt foci の観察 : preneoplastic lesion としての意義

概要

論文の詳細を見る
Studies on aberrant crypt foci (ACF) have been so far carried out with either surgical or autopsied specimens of the colon. In this present study, using magnifying endoscopy (Fujinon Tokyo Japan), we identified ACF in 78 normal subjects (NS), 116 adenoma patients (AP) and 27 cancer patients (CP) and examined their implication as a possible precursor for colon cancer. ACF were readily identified by magnifying endoscopy and showed similar features to those hitherto described in stereoscopic microscopic studies. The incidence, numbers and size of ACF showed stepwise increments in the order of NS, AP, CP. In AP, the numbers of ACF were clearly correlated with the numbers of adenomas. Highly frequent mutations (87.5-100%) of K-ras were found in ACF regardless of cohorts (NS, AP and CP) or sizes. ACF are therefore likely precursors of adenomas and subsequent carcinomas.
札幌医科大学の論文
1997-10-01