鉄酸カリウムK_2FeO_4による糸状性細菌の脱水素酸素活性阻害

概要

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Inhibitory effect of externally added potassium ferrate on behydrogenase activity of intact cells of Sphaerotilus sp. was examined. The enzymic activity was inhibited over 80% by 10 to 15mg-Fe/g-cell at pH6.2. Profile of the inhibition was similar to that of the respiratory inhibition. Inactivated dehydrogenase by only low concentration of ferrate was reactivated by addition of 2-mercaptoethanol (MCE). Kinetic analysis by Lineweaver-Burk plot indicated that the inhibition of dehydrogenase activity by ferrate might be non-competitive. Above mentioned observations suggest that the inhibition of respiration found in Sphaerotilus attacked by low concentration of ferrate might be due not to oxidative destruction of cell wall, but to inactivation of dehydrogenase by some chemical species of iron penetrated the cell wall.
山梨大学の論文