培養神経芽細胞腫に対するレチノイド(ポリプレイン酸E5166)の作用

概要

論文の詳細を見る
Biological activity of E5166, a new class of retinoid, was studied inin vitro system. E5166 was found to suppress the cell proliferation, the syntheses of DNA, RNA and protein, the incorporation of choline into phospholipids and the transport activity of amino acid of GOTO cells, a human neuroblastoma cells. The mode of this inhibitory action was similar to that induced by retinoic acid and retinol, although its potency was somewhat lower than that of these natural vitamins. These results suggest that E5166 may have anti-neoplastic activity as well as other retinoids. On the contrary of the inhibitory effect on amino acid transport, stimulation of sugar transport was induced by E5166. The mechanism of this stimulatory effect was discussed.
園田学園女子大学の論文
1985-03-20