<続発症に関する研究>SHRSP脳におけるスーパーオキサイドジスムターゼ(SOD)活性の変化

概要

論文の詳細を見る
Clinical and experimental evidence demonstrates that nerve cells of spontaneously hypertensive rats (SHR) or stroke-prone spontaneously hypertensive rats (SHRSP) are more sensitive to ischemic injury that those of Wistar Kyoto rats (WKY), and that lipidperoxide increases significantly in the SHRSP brain with aging. To elucidate the vulnerability of SHRSP nerve cells, the activity of SOD, the enzyme that protects cells against reactive free radicals by catalyzing dismutation, was examined in the brain tissues (cerebral cortex and hippocampus)of SHRSP in comparison with that of WKY. There was no significant difference in cerebral cortices between 15-week-old SHRSP and WKY. However, at 31 week old close to the onset of stroke, overall SOD activities in the cerebral cortex of SHRSP were significantly lower than those in WKY. Moreover, SOD activity in the hippocampus, the region of selective neuronal vulnerability, was lower than that in the cerebral cortex of either SHRSP or WKY. These results indicate that low SOD activity in SHRSP is closely related to the vulnerability of SHRSP nerve cells and the increased lipidperoxide of SHRSP brain tissue.
近畿大学の論文
1994-12-30