<原著>プロテウス菌Large Bodyの形成と増殖

概要

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When Proteus mirabilis was incubated with penicillin G or aminobenzyl penicillin (ampicillin) in ordinary broth culture, the formation of spherical forms of the bacteria occurred within 2 or 3 hours after incubation. The gradual increase in size was measured (250 times larger than parent bacteria) up to 6 hours after incubation. However, no cell division of these forms were observed. These spherical forms were designated as large body in this paper. Viability of the large body could be maintained for 7 hours in the presence of osmotic stabilizer such as 5% NaCl. As mentioned above, although no division of the large body occurred in liquid media containing penicillin, the active high molecular synthesis such as DNA, RNA and protein of the largy body was observed in proportion to the parent bacteria. The differences of the antibiotic sensitivities between the large body and the parent bacteria were found in erythromycin and neocarzinostatin among the tested antibiotics. The large body could transformed to L-forms in solid media containing penicillin and horse serum, but not in liquid media. On the other hand, retransformation (reversion) of the large body to parent bacteria occurred in both liquid and solid media in the absence of penicillin. The biological potentialities of the large body as a noncommittal name in this paper were discussed.
近畿大学の論文
1977-06-25