<原著>担子菌由来多糖体Schizophyllan(SPG)の抗ウイルス作用

概要

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The intramuscular injection of SPG enhanced the resistance of the host to the inhalating challenge with influenza A_2 (Kumamoto) at 2 LD_<50>, which resulted in a significant prolongation of the survival time. The similar protective effect of SPG was obtained even when a large dose of the viruses (20 LD_<50>) was adopted to the injection. Moreover, in the mice with experimentally induced HVJ virus infection, SPG given successively before and after the instillation of the viruses strongly suppressed the rapid burst of virus development as assayed by the HAI titer as compared with the untreated control. The glucan also exhibited the suppressive effect on the HAI titer development caused by HVJ infection in EL_4 or S-180 tumor-bearing mice. It is concluded that SPG is potent in the protection of normal and tumor-bearing mice against the experimentally induced virus infection. These and other observation suggest that the SPG stimulation of host defence mechanisms may be coupled to the antiviral action.
1981-09-25