<原著>癌ワクチン療法により誘導される免疫抵抗性に対するSchizophyllanおよびNeocarzinostatinの増強作用

概要

論文の詳細を見る
The potentiating activity of schizophyllan (SPG) and neocarzinostatin (NCS) on the enhanced resistance to the tumors induced by the tumor cell vaccines was evaluated by using two host-syngeneic tumor systems. When combined with glutaraldehyde-concanavalin A treated-L 1210 leukemic cell vaccine, SPG given after the vaccine administration potentiated the immunoprophylactic effect of the vaccine against the subsequent challenge with live L 1210 leukemia, which resulted in the production of the cured animals. In MH 134 hepatoma system, the administration of NCS alone produced a significant prolongation of the life-span, while SPG was without effect. The further study on the potentiating ability of NCS and SPG on the enhanced therapeutic response induced by NCS-treated MH 134 tumor cell vaccine was undertaken. NCS given prior to the tumor inoculation significantly potentiated the effect of vaccine but SPG given in the same manner did not. Moreover, the simultaneous injection of NCS and SPG before and after the tumor inoculation significantly enhanced the efficacy of the vaccine. These results indicate the future applicability of the combined use of SPG and NCS with the tumor cell vaccines for the cancer immunotherapy.
近畿大学の論文
1981-09-25