<原著>抗腫瘍多糖体Schizophyllan(SPG)のインターフェロン産生系に及ぼす影響

概要

論文の詳細を見る
Schizophyllan (SPG) was evaluated for its ability to induce or potentiate the interferon production in vivo and in vitro. The treatment of mice with SPG alone did not affect the serum interferon activity. However, the administration of SPG prior to the E. coli endotoxin injection significantly promoted the endotoxin-induced interferon production. Moreover, SPG given into the mice infected with BCG augmented the induction of interferon production by the secondary sensitization with PPD. When the spleen cells harvested from the mice primed with killed Corynebacterium were stimulated with Corynebacterium in vitro, a small but a significant amount of interferon was produced in vitro. The treatment of mice with SPG in vivo but not the addition of SPG in vitro promoted the interferon production induced by Corynebacterium stimulation in vitro. In conclusion, SPG is potent to augment the production of immune interferons in vitro and in vitro.
近畿大学の論文
1981-09-25