<原著>器官培養法を応用した7,12-Dimethylbenz(α)anthraceneによるラット乳腺組織の発癌におよぼすホルモンの役割

概要

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The experiment was designed for the study on the carcinogenesis of the mammary gland of Wister strain female rats induced by combination of 17β-estradiol, progesterone and prolactin treatment with 7,12-dimethylbenz (α) anthracene in vitro. The highest tumor incidence appeared in the group which had the combination of all hormones with DMBA group. Estrogen is a sine quanon for the induction of mammary cancer, and has its effect as an initiator. Progesterone stimulates significantly the proliferation of the mammary gland, and permits the induction of fibroadenoma, because it may be progesterone-dependent on the stromal cells. Prolactin is not effective for the induction of cancer, but may be needed in lactation. The autoradiographic study on the process of carcinogenesis in vitro was done. DNA synthesis was inhibited during the first 24 hours in the culture, and began to rise after initial lag period. We called it a rebound phenomenon due to neoplastic transformation of the mammary gland epithelial cells by DMBA in vitro.
近畿大学の論文
1976-12-28