<原著>慢性肺疾患患者に対する24時間連続経皮的酸素飽和度測定の有用性について

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Long-term home oxygen therapy (LTOT) that corrects hypoxemia increases survival and improves quality of life in patients with chronic respiratory failure. For performing optimal oxygen prescribe for these patients, we often set up the oxygen flow by a standard short-term education program on admission, for example, by assessment of hemoglobin oxygen saturation (SpO_2) at 6 minutes walking test (6MD). However, it is uncertain whether this kind of method really guarantees adequate oxygen supply in the patient's daily life or not. In the present study, we monitored Sp0_2 all day and tried to clarify profiles of hypoxemia in the daily living of 52 patients with chronic lung disease including chronic obstructive pulmonary disease (COPD),pulmonary fibrosis (IPF) and sequelae of pulmonary tuberculosis (TB-seq). PULSOX-M24^[○!R] (Minolta, Japan) with computer software (DS-M^[○!R], Teijin, Japan) was used. Sp0_2 and pulse rate updated every 5 seconds were continuously recorded for 24 hours. Patients were given an activity log in which they recorded time of their activities and symptoms. The minimal Sp0_2 at 6MD significantly correlated with both minimal Sp0_2 and desaturation time in the daytime, however, not with those at night. Even though Sp0_2 values were over 90% at rest in the daytime, unexpectedly substantial hypoxemia was observed at night in many cases. In the patients with TB-seq, extent and duration of the desaturation at night were worse and longer than those in the patients with COPD or IPF. The present results indicate that the profiles of hypoxia in LTOT patients are not accurately anticipated by the generally performed set-up methods. The continuous whole day monitoring of Sp0_2 is useful, and might be necessary for detailed assessment of profiles of hypoxia at daily living and for optimal setting of oxygen flow, in patients with chronic lung diseases.
愛知医科大学の論文
2003-06-15

<原著>慢性肺疾患患者に対する24時間連続経皮的酸素飽和度測定の有用性について

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