Establishment of in Vivo Metastasis Model of Human Adenoid Cystic Carcinoma : Detection of Metastasis by PCR with Human β-Globin Gene
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概要
- 論文の詳細を見る
Cells from the human adenoid cystic carcinoma (ACC) line, KOA-1, originating from the minor salivary gland and showing histological features of a dominantly solid pattern of ACC, were transplanted into the subcutaneous tissue of nude mice. The occurrence of lung metastasis was then examined both histologically and by PCR with a human-specific base arrangement of the β -globin gene. Histologic examinations revealed lung metastasis in 5 of 30 mice. On the other hand, PCR showed a higher positive rate: 26 of 67 mice (0/10 at 1 month, 5/15 at 2 months, and 21/42 at 3 months after the transplantation). When some lungs which showed positive results by PCR analysis were transplanted into other mice, KOA-1 tumors developed. The results suggested that this experimental model could be a standard in vivo model of metastasis of human ACC.
- 神戸大学の論文
著者
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Komori Takahide
Department of Oral and Maxillofacial Surgery, Kobe University School of Medicine
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Umeda M
Department Of Oral And Maxillofacial Surgery Kobe University Graduate School Of Medicine
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Umeda Masahiro
Department Of Neurosurgery Meiji University Of Oriental Medicine
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Komatsubara Hideki
Kobe University Graduate School of Medicine
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Komori T
Department Of Oral And Maxillofacial Surgery Kobe University School Of Medicine
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Komori Takahide
Department Of Endodontics Showa University School Of Dentistry
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Komatsubara Hideki
Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
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Oku Naohisa
Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
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Oku Naohisa
Department Of Oral And Maxillofacial Surgery Kobe University Graduate School Of Medicine
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Umeda Masahiro
Department Of Medical Informatics Meiji University Of Integrative Medicine
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Umeda Masahiro
Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences
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