Induction Chemotherapy with Docetaxel, Cisplatin and 5-fluorouracil for Tongue Cancer

概要

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Induction chemotherapy consisting of one cycle of docetaxel, cisplatin and5-fluorouracil (5-FU) was evaluated for its primary effects on squamous cell carcinomaof the tongue. The patients were five men and one woman, 50 to 67 (mean 57.8) years ofage. Clinical staging of the tongue cancers showed two patients with stage III and fourwith stage IV disease. All patients underwent one cycle of intravenous chemotherapywith docetaxel (60 mg/m2, on day 1), cisplatin (10 mg/ m2, from days 1 to 5) and 5-FU(500 mg/body, from days 1 to 5) before surgical operation. The overall response ratewas 83.3% (five PRs and one NC), with two cases with grade II A in the Ohboshi &Shimosato classification and four with grade II B. The main side effect was severeneutropenia, which was effectively managed with granulocyte colony-stimulating factor(G-CSF).In conclusion, induction chemotherapy with docetaxel, cisplatin and 5-FU fortongue cancer was tolerated well by all the patients and showed an excellent responserate in spite of only one cycle of administration.
神戸大学の論文