IRF- 1 and IRF-4 Regulate Target Gene Expression via Interaction with DMP 1
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概要
- 論文の詳細を見る
Interferon regulatory factor-4 (IRF-4), a member of the IRF gene family, is a lymphoid-specific transcription factor. IRF-4 deficient mice showed severe immunodeficiencies. Both B- and T-cell activation were profoundly affected: serum immunoglobulin concentrations and antibody responses were decreased, and cytotoxic and antitumor responses were absent in IRF-4 knockout mice. Thus, IRF-4 is essential for the functions of mature B- and T-lymphocytes. To analyze IRF-4 function, we searched for IRF-4- interacting factors. A plasmid was constructed to express a LexA-IRF-4 fusion protein from the inducible GAL1 promoter in yeast cells. When this low copy plasmid (pGilda/IRF-4) was introduced into the yeast strain NOY397, cell growth was significantly inhibited. We supposed that this growth inhibition arose from interference with cellular factors essential for cell viability. We isolated several genes that could rescue the growth inhibition phenotype by screening a yeast genomic library. One of the clones, encoding the REB1 protein, interacted with IRF-4 in vitro. The yeast REB1 protein shares homology with the human transcription factor DMP1. IRF-4 was shown to interact in vitro with DMP1, via its DNA binding domain. IRF-1 also interacted with DMP1. These results suggest that IRF-1 and IRF-4 might regulate target gene expression, via interactions with DMP1.
- 長崎大学の論文
著者
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Matsuyama T
Division Of Cytokine Signaling Department Of Molecular Microbiology And Immunology Nagasaki Universi
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Matsuyama T
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Medicine
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Tomono Kazunori
Nagasaki Univ. School Of Medicine And Dentistry
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Yoshida Kayo
Division Of Cytokine Signaling Department Of Molecular Microbiology And Immunology Nagasaki Universi
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YAMAMOTO Kazuo
Department of Clinical Laboratory Medicine, Shiga University of Medical Science
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Tomono Kazunori
The Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Tomono Kazunori
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Yamamoto Yuuichi
Department of Oncology, Nagasaki University Graduate School of Medicine
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Yamamoto Yuuichi
Department Of Oncology Nagasaki University Graduate School Of Medicine
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Matsuyama Toshifumi
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Medicine
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Kohno Tomoko
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Medicine
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Yamamoto Kazuo
Department Of Biomolecular Sciences Graduate School Of Life Sciences Tohoku University
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Yamamoto Kazuo
Division Of Cytokine Signaling Department Of Molecular Microbiology And Immunology Nagasaki Universi
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Yamamoto Kazuo
Department of Biology, Chiba University
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