Numerical Chromosome Aberrations In A Recurrent Malignant Fibrous Histiocytoma of the Retroperitoneum
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概要
- 論文の詳細を見る
Malignant fibrous histiocytoma (MFH) of the retroperitoneum is relatively rare in Japan. MFHs often recurs even if the tumor is resected completely. We describe a case with recurrent MFH of the retroperitoneum. A 49-year-old male was-admitted to our hospital for a palpable mass in the right lower abdomen. Ultrasonography and computed tomography demonstrated a solid mass with cystic compartment in the lower pole of the right kidney. The tumor was resected completely, and histological examination showed it was MFH, storiform-pleomorphic type. Thirty-three months later, a local recurrence developed and a second operation was performed. The resected tumor was 4.5 テ・3.9 テ・3.1 cm in size and histological diagnosis was recurrent MFH. We also examined the cytological characteristics of the tumor, using DNA flow cytometric quantification and fluorescence in situ hybridization (FISH) with a set of 14 chromosomespecific DNA probes. DNA contents showed a DNA diploid pattern, however, FISH analysis showed various aberrations of chromosome number such as +1, +2, +7, +8, -10, +11, +12, -16, -17, -18, and +20. These results suggested that chromosomal aberrations may reflect a higher biologic aggressiveness of recurrent MFH.
- 長崎大学の論文
著者
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Sawai Terumitsu
First Department Of Surgery Nagasaki University School Of Medicine
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Terumitsu Sawai
First Department Of Surgery Nagasaki University School Of Medicine
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TSUJI TAKASHI
First Department of Surgery, Nagasaki University School of Medicine
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Takashi TSUJI
First Department of Surgery, Nagasaki University School of Medicine
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Eiichiro YAMAGUCHI
First Department of Surgery, Nagasaki University School of Medicine
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Eiichiro Yamaguchi
First Department Of Surgery Nagasaki University School Of Medicine
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Takashi Tsuji
First Department Of Surgery Nagasaki University School Of Medicine
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Yamaguchi Eiichiro
First Department of Surgery, Nagasaki University School of Medicine
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