Patho-, physiological roles of voltage-dependent K^+ channels in pulmonary arterial smooth muscle cells
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概要
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In this review, we demonstrate the basic properties, modulation of, and pathological changes in voltage-dependent K+ (Kv) channels that are expressed in pulmonary arterial smooth muscle cells (PASMCs). Pulmonary Kv channels are thought to play a crucial role in the maintenance of resting membrane potentials, and therefore the vascular tone of the pulmonary arteries. Although the molecular identity of pulmonary Kv channels is not clear, Kv1.1, Kv1.2, Kv1.5, Kv2.1, Kv9.3, and Kv3.1 subtypes are expressed in PASMCs. In addition, resistant PASMCs contain greater amount of Kv channels as compared to conduit PASMCs. This heterogenetic expression of Kv channels is consistent with regional differences in the contractile response to hypoxia. Similar to other K+ channels, pulmonary Kv channels can also be modulated by several vasoconstrictors concomitant with the activation of protein kinase C (PKC). Alterations in Kv channel function have several additional and interrelated consequences, including the regulation of cell proliferation and apoptosis, which ultimately lead to pulmonary vascular remodeling. Increased pulmonary vasoconstriction in pulmonary arterial hypertension is attributable to decreased expression and activity of Kv channels in smooth muscle cells. Kv channels play a central role in the maintenance of cellular homeostasis and ion channels, and consequential signaling cascades. Therefore, Kv channels are potential therapeutic targets for the treatment of pulmonary vascular disease.
- 日本平滑筋学会の論文
- 2010-04-01
著者
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Han Jin
Department Of Physiology College Of Medicine Inje University
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Park Won
Department Of Physiology College Of Medicine Kwangwon National University
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Ko Eun
Department Of Physiology College Of Medicine Inje University
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Park Won
Department Of Bioenergy Science And Technology Bioenergy Research Institute College Of Agriculture A
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Ko Eun
National Research Laboratory For Mitochondrial Signaling Department Of Physiology College Of Medicin
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Han Jin
National Research Laboratory For Mitochondrial Signaling Department Of Physiology College Of Medicin
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FIRTH Amy
Laboratory of Genetics, The Salk Institute for Biological Studies
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Firth Amy
Laboratory Of Genetics The Salk Institute For Biological Studies
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