Physiological roles of K^+ channels in vascular smooth muscle cells(Hirosi Kuriyama Award 2007 Memorial Review)
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概要
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In this review, we present the basic properties, physiological functions, regulation, and pathological alterations of four major classes of K^+ channels that have been detected in vascular smooth muscle cells. Voltage-dependent K^+ (Kv) channels open upon depolarization of the plasma membrane in vascular smooth muscle cells. The subsequent efflux of K^+ through the channels induces repolarization to the resting membrane potential. Changes in the intracellular Ca^<2+> concentration and membrane depolarization stimulate large-conductance Ca^<2+>-activated K^+ (BK_<Ca>) channels, which are thought to play an important role in maintaining the membrane potential. ATP-sensitive K^+ (K_<ATP>) channels underscore the functional bond between cellular metabolism and membrane excitability. The blockade of K_<ATP> channel function results in vasoconstriction and depolarization in various types of vascular smooth muscle. Inward rectifier K^+ (Kir) channels, which are expressed in smooth muscle of the small-diameter arteries, contribute to the resting membrane potential and basal tone. Kir channel activation has been shown to raise the extracellular K^+ concentration to 10-15mM, resulting in vasodilation. Each of K^+ channels listed above is responsive to a number of vasoconstrictors and vasodilators, which act through protein kinase C (PKC) and protein kinase A (PKA), respectively. Impaired Kv, K_<ATP>, and Kir channel functions has been linked to a number of pathological conditions, which may lead to vasoconstriction.
- 日本平滑筋学会の論文
著者
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Han Jin
Department Of Physiology College Of Medicine Inje University
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Park Won
Department Of Physiology College Of Medicine Kwangwon National University
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Ko Eun
Department Of Physiology College Of Medicine Inje University
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KO Eun
National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Departm
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HAN Jin
National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Departm
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JUNG In
Department of Microbiology and Immunology and National Research Laboratory of Dentritic, Cell Differ
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PARK Won
National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Departm
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Jung In
Dep. Of Microbiology And Immunology And National Res. Lab. Of Dendritic Cell Differentiation & R
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Park Won
National Cri Center For Semiconductor Nanorods And Department Of Materials Science And Engineering
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Jung In
Department Of Microbiology And Immunology And National Research Laboratory Of Dendritic Cell Differe
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Ko Eun
National Research Laboratory For Mitochondrial Signaling Department Of Physiology College Of Medicin
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Han Jin
National Research Laboratory For Mitochondrial Signaling Department Of Physiology College Of Medicin
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