Release of Serum S-100β Protein and Neuron-Specific Enolase after Off-Pump Coronary Artery Bypass Grafting with and without Intracranial and Cervical Artery Stenosis
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概要
- 論文の詳細を見る
Purpose: The aim of this study was to quantify the amount of brain damage suffered by patients who underwent off-pump coronary artery bypass grafting (OPCAB) in which S-100β protein and neuron-specific enolase were used. Methods: Thirty-four patients undergoing scheduled OPCAB were enrolled in the study. The patients were divided into two groups according to the results of their magnetic resonance angiography (MRA) and cervical ultrasonography: 13 patients had cervical or intracranial arterial stenosis (Group A), and 21 patients did not (Group B). Blood samples were collected from the arterial catheters immediately before surgery, upon arrival to the intensive care unit, and 6 and 24 hours after surgery. Results: In blood samples collected from patients upon arrival to the intensive care unit, the maximum concentration of serum s-100β protein in Group A was significantly higher than that of Group B (p = 0.029). Though patients in Group A tended to have higher maximum neuron-specific enolase (NSE) concentrations, there were no significant differences in NSE concentrations at any point between the two groups.Conclusions: Our findings show a correlation between the stenosis detected by MRA or cervical ultrasonography and brain damage after OPCAB.
- Annals of Thoracic and Cardiovascular Surgery 編集委員会の論文
- 2011-02-01
著者
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Imamaki Mizuho
千葉大学医学部附属病院 心臓血管外科
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Imamaki Mizuho
Division Of Cardiovascular Surgery Department Of Surgery Chiba University Hospital
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Imamaki Mizuho
Cardiovascular Surgical Service Department Of Surgery Chiba Graduate School Of Medicine
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Imamaki Mizuho
千葉大学 医学研究院臓器制御外科学心臓血管外科
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Imamaki Mizuho
Department Of General Surgery Graduate School Of Medicine Chiba University
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Imamaki Mizuho
鹿島労災病院
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Masuda Masahisa
National Hospital Organization Chiba Medical Center
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Niitsuma Yuriko
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Niitsuma Yuriko
Division Of Cardiovascular Surgery Department Of Surgery Chiba University Hospital
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SHIMURA Hitoshi
Department of Cardiovascular Surgery, Chiba University Hospital
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Masuda Masahisa
Department Of General Surgery Graduate School Of Medicine Chiba University
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Tamura Atsushi
Department Of Applied Chemistry Faculty Of Science Tokyo University Of Science
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Shimura Hitoshi
Division Of Cardiovascular Surgery Department Of Surgery Chiba University Hospital
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Shimura Hitoshi
Department Of General Surgery Graduate School Of Medicine Chiba University
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Miyazaki Masaru
Department Of General Surgery Chiba University
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Tamura Atsushi
Department Of Surgery Division Of Cardiovascular Surgery Graduate School Of Medicine Chiba Universit
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