Detection of COL1A1-PDGFB Fusion Transcripts in Dermatofibrosarcoma Protuberans
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概要
- 論文の詳細を見る
Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon infiltrative tumor of thedermis and subcutaneous tissue. Recent cytogenetic studies have demonstrated a chromosomal translocationof the collagen type I alpha 1 (COL1A1)gene on chromosome 17 to the platelet-derived growthfactor B-chain (PDGFB) gene on chromosome 22. Various exons of the COL1A1 gene have beenreported to be involved in the fusion with exon 2 of the PDGFB gene. M ethod: The COL1A1-PDGFBfusion transcript was detected by reverse transcriptase-polymerase chain reaction (RT-PCR)using frozentissue from 4 DFSP patients. Nucleotide sequence analyses were carried out using the PCR products toidentify the breakpoints. Results : COL1A1-PDGFB fusion transcripts were detected in all tumorspecimens. Sequence analyses revealed that the end of exon 25, 45, 32, or 11 in the COL1A1 gene wasfused with the start of exon 2 in the PDGFB gene. Conclusion : Detection of this aberrant fusiontranscript can be useful as a diagnostic method for DFSP.
- 北関東医学会の論文
著者
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ISHIKAWA Osamu
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
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Okada Etsuko
群馬大学 大学院医学系研究科皮膚病態学
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TAMURA Atsushi
Department of Pharmacology, Chiba University Graduate School of Medicine
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Tamura Atsushi
Department Of Dermatology Gunma University School Of Medicine
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Ishikawa Osamu
Department Of Dermatology Gunma University Graduate School Of Medicine
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Tamura Atsushi
Department Of Dermatology Gunma University Graduate School Of Medicine
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OKADA Etsuko
Department of Dermatology, Gunma University Graduate School of Medicine
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Yasuda Masahito
Department of Dermatology, Gunma University Graduate School of Medicine
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Okada Etsuko
Department Of Dermatology Gunma University Graduate School Of Medicine
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Yamanaka Masayoshi
Department Of Dermatology Gunma University Graduate School Of Medicine
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Yasuda Masahito
Department Of Dermatology Gunma University Graduate School Of Medicine
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Tamura Atsushi
Department Of Applied Chemistry Faculty Of Science Tokyo University Of Science
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