FOXO3 Knockdown Accelerates Development of Bovine Primordial Follicles
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概要
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The objective of the present study was to elucidate the involvement of FOXO3 in the activation of bovine primordial follicles. In immunohistochemistry, FOXO3 was detected in all of the oocytes in primordial and primary follicles. The FOXO3 decreased after treatment with FOXO3 small interfering RNAs (siRNAs). Ovarian tissues containing dominantly primordial follicles were treated with FOXO3 siRNAs and then xenografted to severe combined immune deficiency (SCID) mice. Two months after xenografting, some primordial follicles developed to the secondary and tertiary stages, and the total percentage of these developing follicles (secondary and tertiary follicles: 18 ± 7%) was higher than in the control grafts treated with control siRNA (7 ± 1%). It is thought that bovine primordial follicle activation is regulated by the FOXO3-dependent mechanism and that knockdown of FOXO3 induces the release of primordial follicles from FOXO3 suppression, initiating their growth.
- 2011-08-01
著者
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MIYANO Takashi
Graduate School of Agricultural Science, Kobe University
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Miyano Takashi
Graduate School Of Agricultural Sci. Kobe Univ.
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Miyano Takashi
Laboratory Of Reproductive Biology & Biotechnology Faculty Of Agriculture Kobe University
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Miyano T
Laboratory Of Reproductive Biology And Biotechnology Faculty Of Agriculture Kobe University
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Bao Rong-mei
Graduate School Of Agricultural Science Kobe University
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TAKETSURU Hiroaki
Graduate School of Agricultural Science, Kobe University
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Taketsuru Hiroaki
Graduate School Of Agricultural Science Kobe University
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Moniruzzaman Mohammad
Graduate School Of Agricultural Science Kobe University
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Hayakawa Kohei
Graduate School Of Agricultural Science Kobe University
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